Entrophy/Enthalpy Compensation
Bibliographic References tagged with Entrophy/Enthalpy Compensation
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G. B. Sigal and G. M. Whitesides. 1996. “Benzenesulfonamide-Peptide Conjugates As Probes for Secondary Binding Sites Near the Active Site of Carbonic Anhydrase”. Bioorg. & Med. Chem. Lett., 6, Pp. 559-64
G. B. Sigal and G. M. Whitesides. 1996. “Benzenesulfonamide-Peptide Conjugates As Probes for Secondary Binding Sites Near the Active Site of Carbonic Anhydrase”. Bioorg. & Med. Chem. Lett., 6, Pp. 559-64
M. Mammen, E. I. Shakhnovich, and G. M. Whitesides. 1998. “Using a Convenient, Quantitative Model for Torsional Entropy To Establish Qualitative Trends for Molecular Processes That Restrict Conformational Freedom”. Journal of Organic Chemistry, 63, Pp. 3168-75
M. Mammen, E. I. Shakhnovich, and G. M. Whitesides. 1998. “Using a Convenient, Quantitative Model for Torsional Entropy To Establish Qualitative Trends for Molecular Processes That Restrict Conformational Freedom”. Journal of Organic Chemistry, 63, Pp. 3168-75
D. N. Chin, A. Y. Lau, and G. M. Whitesides. 1998. “Studying How Different Terminal Groups Change the Motion of H2NSO2C6H4CONH(EG)3R When Bound to the Active Site of Human Carbonic Anhydrase II”. Journal of Organic Chemistry, 63, Pp. 938-45
D. N. Chin, A. Y. Lau, and G. M. Whitesides. 1998. “Studying How Different Terminal Groups Change the Motion of H2NSO2C6H4CONH(EG)3R When Bound to the Active Site of Human Carbonic Anhydrase II”. Journal of Organic Chemistry, 63, Pp. 938-45
G. M. Whitesides and V.M. Krishnamurthy. 2005. “Designing Ligands to Bind Proteins”. Quarterly Reviews of Biophysics, 38, Pp. 385-95
G. M. Whitesides and V.M. Krishnamurthy. 2005. “Designing Ligands to Bind Proteins”. Quarterly Reviews of Biophysics, 38, Pp. 385-95
V.M. Krishnamurthy, L. A. Estroff, and G. M. Whitesides. 2006. “Multivalency in Ligand Design”. In Fragment-Based Approaches in Drug Discovery, edited by R. Mannhold, H. Kubinyi, and G. Folkers, 34:Pp. 11-53. Weinheim: WILEY-VCH Verlag GmbH & Co.
V.M. Krishnamurthy, L. A. Estroff, and G. M. Whitesides. 2006. “Multivalency in Ligand Design”. In Fragment-Based Approaches in Drug Discovery, edited by R. Mannhold, H. Kubinyi, and G. Folkers, 34:Pp. 11-53. Weinheim: WILEY-VCH Verlag GmbH & Co.
V.M. Krishnamurthy, V. Semetey, P. J. Bracher, N. Shen, and G. M. Whitesides. 2007. “Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System”. J. Amer. Chem. Soc., 129, Pp. 1312-20
V.M. Krishnamurthy, V. Semetey, P. J. Bracher, N. Shen, and G. M. Whitesides. 2007. “Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System”. J. Amer. Chem. Soc., 129, Pp. 1312-20
G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins”. In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, Ch. 9, Pp. 189-215. London: Imperial College Press
G. M. Whitesides, P. W. Snyder, D. T. Moustakas, and K. A. Mirica. 2008. “Designing Ligands to Bind Tightly to Proteins”. In Physical Biology: From Atoms to Medicine, edited by A. H. Zewail, Ch. 9, Pp. 189-215. London: Imperial College Press
B. A. Grzybowski, A. V. Ishchenko, C. Y. Kim, G. Topalov, R. G. Chapman, D.W. Christianson, G. M. Whitesides, and E. I. Shakhnovich. 2002. “Combinatorial Computational Methods Give New Picomolar Ligands for a Known Enzyme”. Proc. Nat. Acad. Sci. USA, 99, Pp. 1270-73
B. A. Grzybowski, A. V. Ishchenko, C. Y. Kim, G. Topalov, R. G. Chapman, D.W. Christianson, G. M. Whitesides, and E. I. Shakhnovich. 2002. “Combinatorial Computational Methods Give New Picomolar Ligands for a Known Enzyme”. Proc. Nat. Acad. Sci. USA, 99, Pp. 1270-73
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy Enthropy Compensation in Protein-Ligand Binding”. J. Amer. Chem. Soc., 135, Pp. 15579-84
B. Breiten, M. R. Lockett, W. Sherman, S. Fujita, M. Al-Sayah, H. Lange, C. M. Bowers, A. Heroux, G. Krilov, and G. M. Whitesides. 2013. “Water Networks Contribute to Enthalpy Enthropy Compensation in Protein-Ligand Binding”. J. Amer. Chem. Soc., 135, Pp. 15579-84
J. Mecinovic, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Herous, and G. M. Whitesides. 2011. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the ‘Hydrophobic Wall’ of Carbonic Anhydrase”. J. Amer. Chem. Soc., 133, Pp. 14017-26
J. Mecinovic, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Herous, and G. M. Whitesides. 2011. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the ‘Hydrophobic Wall’ of Carbonic Anhydrase”. J. Amer. Chem. Soc., 133, Pp. 14017-26